RWE Evidence Synthesis Senior Associate

• Location: Barcelona, Spain

Our Team:

Sanofi Business Operations is an internal Sanofi resource organization based globally and is setup to centralize processes and activities to support Specialty Care, Vaccines, General Medicines, CMO, and R&D, Data & Digital functions. Sanofi Business Operations strives to be a strategic and functional partner for tactical deliveries to Medical, Market Access, and Commercial organizations in Sanofi, globally.

Main responsibilities:

The RWE Evidence Synthesis Senior Associate is responsible for conducting systematic and targeted literature reviews, as well as scoping and rapid reviews that align with real-world evidence needs. In this role, you will draft research protocols, define PICOTS questions, and manage data extraction and methodological descriptions. You will write technical narratives summarizing study designs, patient populations, and findings generated from registries, claims, and EHR datasets. Collaboration with statisticians is a key component, as you will translate results from indirect treatment comparisons (MAIC, STC) and network meta-analyses into clear, scientifically accurate reports and manuscripts. You are also responsible for ensuring all deliverables comply with PRISMA, ISPOR, NICE, and IQWiG standards, while maintaining audit-ready documentation such as search strings and screening logs. Finally, you will support cross-functional teams in HEOR and Medical Affairs by producing evidence summary slide decks and HTA-support documents.

• Author SLRs, TLRs, scoping reviews, and rapid reviews with strong alignment to RWE needs.

• Draft protocols, research questions (PICOTS), data extraction forms, and methodological descriptions.

• Write high‑quality narratives summarizing study designs, RWE endpoints, patient populations, comparators, and analytical methods.

• Write methods sections, search documentation, and study attrition summaries, and Synthesize extracted data into structured evidence tables, GRADE assessments, and narrative summaries.

• Write summaries of findings generated from real‑world data (registries, claims/EHR datasets, observational studies).

• Collaborate with statisticians to translate results into clear, concise, scientifically accurate text, figures, and tables.

• Document methodological rigor: bias assessment, confounding control, causal inference methods, and RWE trial emulation principles.

• Produce publication‑ready reports, manuscripts, HTA-support documents, and evidence summary slide decks.

• Ensure compliance with PRISMA, ISPOR, NICE, IQWiG, and global RWE methodology standards.

• Prepare audit‑ready documentation (search strings, screening logs, PRISMA diagrams).

• Collaborate with HEOR, epidemiology, RWE analytics, clinical, medical affairs, and regulatory teams.

• Translate complex analytical output into clear and concise written insights for cross‑functional stakeholders.

• Support external vendor oversight for written deliverables.

• Develop the written components of Indirect treatment comparisons (Bucher, MAIC, STC), Network meta-analyses (frequentist or Bayesian), Evidence networks, assumptions, and sensitivity analyses.

• People: (1) Consult with Medical Affairs, Market access, and Real World Evidence Investigators and cross‑functional partners to ensure timely planning, execution, and delivery of evidence synthesis outputs (SLRs, TLRs, NMAs, ITCs). (2) Work effectively with statisticians, epidemiologists, and RWE analytics teams to ensure methodological and scientific rigor in comparative evidence deliverables. (3) Support internal stakeholders in understanding evidence synthesis methods, results, and implications for medical, regulatory, and HEOR strategies.

• Performance: (1) Ensure Evidence synthesis outputs (SLRs, TLRs, NMAs, ITCs) meet scientific, methodological, and compliance standards. (2) Projects are completed within agreed timelines, enabling downstream deliverables (submissions, publications, internal strategy documents). (3) Deliverables demonstrate strong methodological integrity, clear interpretation, and flawless documentation (search logs, PRISMA, QA). (4) Effective communication of complex comparative evidence results enabling informed decision‑making across clinical, medical, and access functions.

• Process: (1) Lead the design, execution, and writing of SLRs, TLRs, direct (pairwise) meta‑analyses, network meta‑analyses (NMAs), and indirect treatment comparisons (ITCs). (2) Translate complex analytical outputs (NMA/ITC/statistical models) into clear, accurate, and publication‑quality scientific narratives for use in reports, submissions, and manuscripts. (3) Ensure adherence to PRISMA, ISPOR, and global best‑practice standards for methodology, documentation, and reporting. (4) Ensure evidence and comparative analyses are correctly interpreted, documented, and aligned with external stakeholder expectations. (5) Provide methodological and statistical interpretation support to Medical Affairs, Market Access, Biostatistics, and RWE teams.

• Stakeholder: (1) Deliver high‑quality evidence synthesis and comparative evidence outputs that support RWE strategy, evidence generation plans, and medical/payer needs for General Medicines and other therapeutic areas. (2) Ensure effective, timely, and transparent communication of project status, risks, dependencies, and scientific considerations to all stakeholders.

About you

• Experience: Minimum 2 years hands-on experience in evidence synthesis, including authoring SLRs, TLRs, scoping reviews, and rapid reviews.

Experience working in Real-World Evidence (RWE) environments, with additional background in pharmaceutical, CRO, HEOR, or epidemiology settings supporting cross-functional evidence needs. Previous experience with submissions to regulatory and/or core value dossier development. Good knowledge of technical guidelines (e.g., NICE, EU, HTA, IQWiG). Competence with tools such as RevMan, GRADEpro.

• Soft skills: Strong communication skills to collaborate effectively with cross-functional teams Strong organizational, documentation, and project management abilities. Ability to function autonomously and manage the delivery of projects with quality control. Ability to manage multiple priorities and deliver within tight timelines.

• Education: MSc or PhD in epidemiology, pharmacoepidemiology, public health, or life sciences field with additional training in systematic review methodology, comparative effectiveness or real-world evidence

• Languages: Excellent communication skills in English, both written and oral

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