AstraZeneca is a global, science-led biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines. As a FTSE 100 company with a presence in over 100 countries, it operates at a massive scale, employing nearly 90,000 people worldwide across therapy areas such as Oncology, Rare Diseases, and Cardiovascular, Renal & Metabolism.

In Spain, AstraZeneca maintains a robust presence with its commercial headquarters in Madrid and a significant global innovation hub in Barcelona. The company is a major employer for international talent, particularly in clinical research, data science, and regulatory affairs. Their Spanish operations are characterized by a multicultural environment and a strong emphasis on professional development, making them a top choice for expatriates in the life sciences sector.

AstraZeneca was formed in 1999 through the merger of the Swedish company Astra AB and the British Zeneca Group PLC. It has since evolved into a global pharmaceutical leader, notably playing a key role in the global response to the COVID-19 pandemic.

Senior Clinical PBPK Modeling Scientist

AstraZeneca

Original Advert

The ideal candidate will havestrongbackground in pharmacokinetics and translational modeling. You willparticipatein implementing innovative and quantitative approaches to advance clinical drug development.Developing, qualifying, and applying mechanistic PBPK modelsusing invitro, preclinical, clinical, and literature data to support clinical development decisions across therapyareas.In addition, you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology(CPQP)asperyour experience, interests,andexpertisedictate.

Typical Accountabilities

Utilizephysiologically-basedpharmacokinetic (PBPK)and translational modeling tools to enable clinical PK projections fordrug-drug interactions (DDIs), pediatric and other specific populations, and other clinical development questions

Collaborate withDrug Metabolism and Pharmacokinetic (DMPK) Scientistsand Clinical Pharmacology scientists to generate these mechanistic models

Develop fit-for-purpose, qualified PBPK models suitable for internal decision-making and regulatory use, including support forsubmissiondocumentation and health authorityinteractions.Communicateclearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions

Keep up to date with emerging literature, modeling science, and regulatory expectations

Education, Qualifications,Skillsand Experience

Essential

PhD degree preferred or equivalent (M.Sc./Pharm.D.)

Experience using PBPK platforms such asSimcyp,GastroPlus, or PK-Sim, together with scripting in R and/or Python for data analysis, visualization, and workflow automation.

Familiarity with AI-enabled scientific workflows, such as literature mining, codingassistance, or document summarization in compliant research environments

Demonstrated broadPBPKexpertiseand experience exemplified by 1-4 Years of drug development experience, with emphasis onPBPK modelling

Good knowledge inpharmacokinetics, drug-drug interactions, regulatory guidance in clinical pharmacology,modellingand simulation sciences

Demonstrated ability toidentify,developand executePBPKactivities at a project level

Good oral and written communication skills

Good knowledge of global regulatory, compliance, processes,standardsand issues specific toPBPK

with relevant experiencerequired

Experience authoring or contributing to PBPK technical reports and regulatory documentation, including submission-ready analyses and responses to health authority queries.Fluency in spoken and written English language

Desirable

Areputation gained from scientific publishing in the field of DMPK/Clinical Pharmacology

Experience in early andlate-stagedrug development

Date Posted

03-jul-2026

Closing Date

16-jul-2026

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.