Postdoctoral Fellow for the Colorectal Cancer Laboratory

• Experience

- Doctoral degree in Life Sciences (Biology, Biotechnology, Biomedicine, or a related field). Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment.

- Official Accreditation to perform Animal Experimentation

• Knowledge and skills

- Strong background in Tumour Immunology

- Verified skills in cell culture and Molecular Biology

- Good knowledge of Antibody-based tissue analyses, including FACS analyses of tumor cell populations and analysis of imaging data

- Verified skills in In vivo experiments

- Fluent in English.

• Competences

- Self-Motivated

- Good communication skills, both for oral presentations as well as for scientific writing

- High organization capacity

- Ability to interact effectively and work within a team

- Good analytical and problem-solving skills

• Experience

- Organoid Culturing

- At least one (first-author) research paper during your PhD

- Proven experience in immunology

• Knowledge

- Candidates with experience with big data analyses, and coding with R and/or Python will be prioritized.

To be a part a part of something meaningful: We are a biomedical research centre that tirelessly works to achieve a society free of diseases. Our mission is to carry out research of excellence to cure cancer and other diseases linked to ageing.

Good Working conditions: Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leave and injuries at work.

Competitive salary: commensurate with experience and qualifications.

International Environment: Nearly 90 Postdoctoral researchers (more than a half non-Spanish nationals) are currently working at IRB Barcelona.

Multidisciplinary Research: Research of excellence at the unique interface between biology, chemistry, and structural and computational biology.

Training and Career: Postdoctoral researchers joining IRB Barcelona gain access to the Institute's advanced research training and career development opportunities, all within in a competitive international environment. Courses and workshops on themes of particular interest to postdocs are offered regularly by the Institute.

Relocation & Visa Assistance: Trained staff provides support on visa paperwork, administrative requirements, and practical information on living and working in Barcelona, etc.

Social Life: We like to have fun. We promote several activities, like a Football League, an annual skiing trip, a Mountaineering Club, a Running Club and "Cool-off sessions", where members meet informally for drinks, snacks and scientific discussions.

Fairness: Our recruitment is open, transparent and merit-based, and all applicants compete on the same terms. We are an Equal Opportunity Employer and all qualified applicants are considered for employment without regard to race, colour, religion, age, sex, sexual orientation, gender identity, nationality, ethnic origin or disability.

IRB Barcelona is seeking an enthusiastic, motivated and ambitious Postdoctoral fellow to join the Colorectal Cancer Laboratory (led by Dr. Eduard Batlle) at the Cancer Science Programme. The Batlle Lab at IRB Barcelona is an international reference for the study of colorectal cancer (CRC). Their pioneering studies have contributed to advance the state of the art in several important areas such as the connection between stem cells and cancer, the role of the tumor microenvironment in poor prognosis CRC and the identification of mechanisms of metastasis and immune evasion. Further information can be found at: https://www.irbbarcelona.org/en/research/colorectal-cancer-laboratory#eduard-batlle and https://www.icrea.cat/community/icreas/17443/eduard-batlle-gomez/

The successful candidate will develop an exciting project aiming to understand immune-evasion mechanisms in metastatic dissemination and disease relapse. It will make use of KRAS inhibitors to study tumour cell plasticity and persister-cells. The approach is multidisciplinary and aims to translate basic research to clinically relevant data, using animal and cell models, as well as genetic profiles of tumour samples. The project involves state of the art technologies including FACS, scRNAseq; genetic editing by Crispr/Cas; in vivo models of immunocompetent metastatic cancer based on organoids; spatial tissue profiling and advanced methods of microscopy.