Research Technician in the Epigenetic Events in Cancer Lab

• You have 5 years of experience in molecular biology; gene regulation; epigenetics
• You have proven experience ChIP and mouse development
• You are fluent in English
• You have previous experience in the field of molecular and cellular biology
• You have advance knowledge of bioinformatic analysis
• You have knowledge of molecular biology techniques (general DNA and RNA manipulation techniques including purification, cloning, mutagenesis, PCR, RT-PCR, qPCR)
• You have knowledge of chromatin Immunoprecipitation
• You have knowledge of proteomic techniques (protein extraction, subcellular fractionation,

western blot, protein-protein interaction techniques)

• You have experience with cell culture of primary and stablished cell lines
• Highly developed organizational skills
• You are a highly motivated and organized candidate
• You are capable of working in a group and with a high degree of work autonomy

• You hold a PhD in Biology or equivalent

• You are proficient in English

We are seeking a highly motivated candidate to join our team to work on an interdisciplinary project. The candidate must be mastered several techniques, such as general DNA and RNA manipulation techniques purification, cloning, mutagenesis, PCR, RT-PCR, qPCR, chromatin Immunoprecipitation, proteomic techniques (protein extraction, subcellular fractionation, western blot, protein-protein interaction techniques), FACS and cell culture of primary and stablished cell lines.

Understanding the genetic basis of cancers has been a topic of intense research, and hundreds of gene mutations have been identified that can cause carcinogenesis. However, in the past few years, increasing evidence has suggested that mutations are not the only genetic changes that lead to cancer. Indeed, perturbations of chromatin structure and of other epigenetic mechanisms can cause inappropriate gene expression and genomic instability, resulting in cellular transformation and malignant outgrowth.

Our research investigation is focused on understanding the role of several protein complexes that are involved in chromatin dynamics and metabolism, which when altered could participate in the establishment and maintenance of the aberrant silencing of tumor suppressor genes during transformation.

• Contract duration: Until March 31 2027, temporay contract
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales
• Target start date: 1/11/2026

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.

We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.

The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.