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Senior Research Technician – Deep Mutational Scanning of Membrane Proteins

On-site in Barcelona·Added today

Centre for Genomic Regulation

10 open roles

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What they ask for

  • Have the right to work in Spain

    Centre for Genomic Regulation doesn't mention sponsorship in the ad.

  • Work in English

    English is required, per the ad.

  • Work on-site in Barcelona

    No relocation package mentioned.

  • Have senior-level experience

    Senior-level role.

The role

We are looking to hire a Senior Research Technician join a large-scale project performing deep mutational scanning of membrane proteins. The role involves variant library design, library generation, selections in human cell lines, DNA sequencing library generation and data analysis.

The focus of Lehner lab is using massively parallel selection experiments to tackle the fundamental encoding problems of molecular biology. Towards this goal we have developed, benchmarked, and applied at scale experimental methods that use DNA synthesis-selection-sequencing to perform biophysical measurements including quantifying how changes in sequence alter protein stability, binding affinity, aggregation, allostery and expression. We have used these methods to produce the first comprehensive maps of long-range allsoteric communication in proteins, to quantify the effects of >500,000 variants in >500 human proteins, and to probe the genetic architecture of proteins, protein interactions, and RNAs. A key component of this work has been the development of computational methods for analyzing deep mutational scanning data and for fast and flexible fitting of mechanistic and statistical models to the data. Our current focus is on generating datasets of sufficient size and diversity to train machine learning models to accurately predict how changes in sequence alter molecular biology.

Requirements

What we're looking for

Must Have
• You have extensive experience in molecular biology including large-scale data generation and, ideally, deep mutational scanning
• You have extensive experience in the analysis of sequencing datasets

Technical skills
• You have advanced molecular biology skills
• You have developed and optimised new experimental protocols
• You keep meticulous records

Competences
• You can work in an interdisciplinary team
• You can plan, optimise and execute complex protocols
• You can work independently and have experience of project management
• You have very good organizational skills

Nice to have

Desirable but not required/ Nice to have
• Experience in statistical data analysis and bioinformatics
• Experience in high-throughput genomics

Education & certifications

• You hold a PhD or master's degree in molecular biology or a related discipline

Languages

Languages
• You are proficient in English

Pay & benefits

What you'll get

The Offer - Working Conditions
• Contract duration: Temporary contract, 6 months
• Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales
• Target start date: October 2026

We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.

Hiring process

All applications must include:
1. A motivation letter addressed to Prof. Ben Lehner
2. A complete CV including contact details.
3. Contact details of two referees.

All applications must be addressed to Prof. Ben Lehner and be submitted online on the CRG Career site - http://www.crg.eu/en/content/careers/job-opportunities

₋ Pre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.

₋ Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.

₋ Offer Letter: Once the successful candidate is identified the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.

Deadline: Please submit your application by 4/10/2026

Suggestions: The CRG believes in ongoing improvement and promotes a culture of feedback. This is one of the reasons we have in place, at your disposal as a candidate, a mechanism to gather your suggestions/complaints concerning your candidate experience in our recruitment processes. Your feedback really matters to us in our aim at creating a positive candidate journey. You can make a difference and help us improve by letting us know your suggestions through the following form.

About Centre for Genomic Regulation

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, created in July 2000. It is a non-profit foundation funded by the Catalan Government, the Spanish Ministry of Science & Innovation, the 'la Caixa' Banking Foundation, and includes the participation of Pompeu Fabra University. The CRG is based in the Barcelona Biomedical Research Park (PRBB) and is a CERCA centre.

Industry
Genomics research
Founded
2000
Employees
1,000–5,000
Headquarters
Barcelona, Spain
In Spain
Barcelona
Website
crg.eu

Good to know if you are moving

  • The CRG is located in the Barcelona Biomedical Research Park (PRBB), a hub for biomedical research in Barcelona.
  • The institute has an international workforce, with nearly 1,400 people from 48 different countries.
  • The CRG offers a relocation service for international researchers, as indicated by its 'Relocation to Barcelona' section.
  • The institute is a CERCA centre, part of Catalonia's network of research centres of excellence.
  • The CRG has an HR Excellence in Research award from the European Union, indicating commitment to fair and transparent recruitment.

In their own words

About the company & team

The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).

Please, check out our Recruitment Policy

Additional information

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crg_job_advert_seniorresearchtechnician_2026.pdf

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